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Check Carefully (1)phenobarbital will reduce the level or result of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to some lower in fentanyl plasma concentrations, insufficient efficacy or, potentially, progress of th